RKI-057 functions by binding to the kinase domain of RIPK1, thereby blocking its enzymatic activity. RIPK1 is a key upstream mediator in the necroptotic pathway. When inhibited, the formation of the necroptosome complex (RIPK1-RIPK3-MLKL) is prevented, halting the downstream execution of necroptosis. This distinguishes it from apoptosis inhibitors, as it specifically targets programmed necrosis without directly affecting caspase-dependent pathways.
Classification: RKI-057 is a synthetic small molecule identified as a potent and selective inhibitor of Receptor-Interacting Protein Kinase 1 (RIPK1) . It is primarily used in preclinical research for studying necroptosis —a regulated form of necrotic cell death.
Measure your chest (A) and hips (B) following our indications.
The reference measurement will always be the larger of the two (A or B).
Look in the chart to which size corresponds to that measurement.
| Size | Reference measurements | |
|---|---|---|
| Inches | Centimeters | |
| 2XS | 25.6 – 29.4 | 65 – 74 |
| XS | 29.5 – 32.6 | 75 – 82 |
| S | 32.7 – 36.1 | 83 – 91 |
| M | 36.2 – 39.7 | 92 – 100 |
| L | 39.8 – 42.8 | 101 – 108 |
| XL | 42.9 – 46.3 | 109 – 117 |
| 2XL | 46.4 – 49.9 | 118 – 126 |
| 3XL | 50 – 53 | 127 – 134 |
| 4XL | 53.1 – 55.9 | 135 – 142 |